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LETTER TO EDITOR
Year : 2011  |  Volume : 20  |  Issue : 2  |  Page : 146  Table of Contents     

High density lipoprotein: State marker for dependence status of Mahua


1 Department of Psychiatry, Pandit Jawaharlal Nehru Memorial Medical College and Dr. Bhimrao Ambedkar Memorial Hospital, Raipur, Chhattisgarh, India
2 Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India

Date of Web Publication16-Oct-2012

Correspondence Address:
Lokesh Kumar Singh
Department of Psychiatry, Pandit Jawaharlal Nehru Memorial Medical College and Dr. Bhimrao Ambedkar Memorial Hospital, Raipur, Chhattisgarh- 492 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6748.102535

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How to cite this article:
Singh LK, Praharaj SK. High density lipoprotein: State marker for dependence status of Mahua. Ind Psychiatry J 2011;20:146

How to cite this URL:
Singh LK, Praharaj SK. High density lipoprotein: State marker for dependence status of Mahua. Ind Psychiatry J [serial online] 2011 [cited 2020 May 31];20:146. Available from: http://www.industrialpsychiatry.org/text.asp?2011/20/2/146/102535

Sir,

Among the biochemical state markers of alcohol dependence, lipids are given special significance due to their impact on the cardiovascular status. Of the various important alterations created by alcohol on lipid status of the individual, well documented and invariably found is an increase in the High Density Lipoprotien (HDL) concentrations during dependence states of alcoholism. However, the mechanism of this alteration is inadequately understood till date. Perhaps for this, several factors need to be taken into account including the type of alcohol, content of alcohol, dose, duration, association with other biochemical markers etc. In this context, we performed a short term prospective study to find the differences in the HDL profile of the patients admitted in our institute during and after the phase of detoxification of alcohol consumption in the form of a locally brewed alcohol, Mahua. Around 40 male inpatients (mean age of 34.75±7.16 years), with ICD-10 clinical diagnosis of alcohol dependence syndrome without any co-morbid psychiatric disorder or major physical illnesses were included. The sample had 9.35±3.79 years of education, 13.4±6.29 years of dependence on alcohol and 1.09±0.6 liters of average consumption of Mahua per day. Laboratory assessments (Liver Function Test, Lipid profile) were done on baseline (Day 0) and after one month.

Very significant differences were seen in HDL level between the two measurements (P<0.001, effect size=0.856). This finding is consistent with previous findings. [1],[2] However, due to lack of a specific explanation for this phenomenon, several speculations have also been made regarding other possible causes for this increase in HDL levels like effects of exercise and dietary influences. [3] In this view, it becomes important to note whether the effects on HDL are consistent over all the alcohol types. The present study contributes in this respect where its results show that the same finding is found in dependence states of Mahua, which is a locally brewed alcohol made from the flowers and leaves of Mahua trees which has an alcohol content of 20-40%. [4] The biochemical profile of patients with dependence on this type of alcohol has not been studied so far. The results of this study thus contribute to the probability that the increase in HDL levels in alcoholics is due to alcohol per se. There was significant difference between the levels of liver enzymes in two measurements. This finding was reported consistently in many previous studies. In continuation to above finding there was significant positive correlation was found among age, duration of dependence, AUDIT score and liver enzyme levels. Thus, present work also support the deleterious effect of alcohol associated with longer duration of use.

 
   References Top

1.LaPorte R, Valvo-Gerard L, Kuller L, Dai W, Bates M, Cresanta J, et al. The relationship between alcohol consumption, liver enzymes and high density lipoprotein cholesterol. Circulation 1981;64(3 Pt 2):III 67-72.  Back to cited text no. 1
    
2.Huang CM, Elin RJ, Ruddel M, Schmitz J, Linnoila M. The effect of alcohol withdrawal on serum concentrations of Lp(a), apolipoproteins A-1 and B, and lipids. Alcohol Clin Exp Res 1992;16:895-8.  Back to cited text no. 2
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3.Williams PT, Krauss RM, Wood PD, Albers JJ, Dreon D, Ellsworth N. Associations of diet and alcohol intake with high-density lipoprotein subclasses. Metabolism 1985;34:524-30.  Back to cited text no. 3
[PUBMED]    
4.Bennett LA, Campillo C, Chandrashekar CR, Gureje O. Alcoholic beverage consumption in India, Mexico and Nigeria. Alcohol Health Res World 1998;22:243-52.  Back to cited text no. 4
[PUBMED]    




 

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