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CASE REPORT
Year : 2016  |  Volume : 25  |  Issue : 1  |  Page : 119-121

Aripiprazole-induced priapism


1 Department of Psychiatry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal, Madhya Pradesh, India
2 Department of Psychiatry, Ranchi Institute of Neuro-Psychiatry and Allied Health Sciences, Kanke, Ranchi, Jharkhand, India

Correspondence Address:
Ajish G Mangot
OPD-7, C-Block, People's College of Medical Sciences and Research, Centre, Bhanpur, Bhopal - 462 037, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6748.196044

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Priapism is a urologic emergency representing a true disorder of penile erection that persists beyond or is unrelated to sexual interest or stimulation. A variety of psychotropic drugs are known to produce priapism, albeit rarely, through their antagonistic action on alpha-1 adrenergic receptors. We report such a case of priapism induced by a single oral dose of 10 mg aripiprazole, a drug with the least affinity to adrenergic receptors among all atypical antipsychotics. Polymorphism of alpha-2A adrenergic receptor gene in schizophrenia patients is known to be associated with sialorrhea while on clozapine treatment. Probably, similar polymorphism of alpha-1 adrenergic receptor gene could contribute to its altered sensitivity and resultant priapism. In future, pharmacogenomics-based approach may help in personalizing the treatment and effectively prevent the emergence of such side effects.


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